Bold ideas, unjustified anticipations, and speculative thought, are our only means for interpreting nature: our only organon, our only instrument, for grasping her. And we must hazard them to win our prize. Those among us who are unwilling to expose their ideas to the hazard of refutation do not take part in the scientific game.

I believe that the advance of science depends upon the free competition of thought, and thus upon freedom, and that it must come to an end if freedom is destroyed (though it may well continue for some time in some fields, especially in technology).

Science is not a system of certain, or well established, statements; nor is it a statement which steadily advances towards state of finality. Our science is not knowledge (epistēmē): it can newer claim to have attained truth, or even substitute for it, such as probability. . . . We do not know; we can only guess.

Science does not rest upon solid bedrock. The bold structure of its theories arises, as it were, above a swamp. It is like a building erected on piles. The piles are driven down from above into the swamp, but not down to any natural or 'given' base; and if we stop driving the piles deeper, it is not because we have reached firm ground. We simply stop when we are satisfied that the piles are firm enough to carry the structure, at least for the time being.

The game of science is, in principle, without end. He who decides one day that scientific statements do not call for any further test, and that they can be regarded as finally verified, retires from the game.

...no matter how many instances of white swans we may have observed, this does not justify the conclusion that all swans are white.

Good tests kill flawed theories; we remain alive to guess again.

Philosophers should consider the fact that the greatest happiness principle can easily be made an excuse for a benevolent dictatorship. We should replace it by a more modest and more realistic principle - the principle that the fight against avoidable misery should be a recognized aim of public policy, while the increase of happiness should be left, in the main, to private initiative.

Those who promise us paradise on earth never produced anything but a hell.

If the many, the specialists, gain the day, it will be the end of science as we know it - of great science. It will be a spiritual catastrophe comparable in its consequences to nuclear armament.